An introduction to Ibutamoren (MK-677)
Contrary to popular beliefs and lots of published information online, Ibutamoren is a growth hormone secretagogue and not a selective androgen receptor modulator. Here is the thing, SARMs such as Ligandrol, Ostarine, and many others work by stimulating the androgen receptors found in your muscle tissues. That is basically why they are called Selective Androgen Receptor Modulators. When we look at Ibutamoren, the mechanism is entirely different. This particular compound works by promoting the secretion of growth hormone, and that is why it is referred to as a growth hormone secretagogue.
The truth of the matter is that Ibutamoren is commonly categorized as a SARMs simply because it helps to achieve the same bodybuilding effects while remaining safe for the body. This compound also referred to as Ibutamoren Mesylate or Nutrobal has a very unique approach when it comes to enhancing performance. That is also one of the reasons why there is a lot of skepticism surrounding the compound and its ability to achieve the sort of results it is associated with.
Trials are always known to deliver an outcome that no one expected. Scientists will develop a compound and start investigating it for particular reasons only to end up with completely different results. We can just imagine how frustrating this may be to them, but in most cases, it is always good news to someone else. Take Ibutamoren, for instance, this substance was initially supposed to be a medicinal compound intended for the stimulation of pituitary gland to secrete growth hormone in individuals with GH deficiency. Reverse Pharmacology, the company behind MK-677, ended up creating a substance that will become widely used in the bodybuilding industry even though they intended to deal with issues such as osteoporosis, muscle wasting, obesity, bone fractures, etc.
Mk-677 became so effective in promoting the release of IGF-1. It helped fitness enthusiasts to increase their lean muscles mass in record time. The best part? This substance achieved all this in a very safe manner unlike most of the other performance enhancing drugs that were available at the time. Fast forward to over two decades later and Mk-677 is still widely used in the fitness industry.
Benefits of Ibutamoren
Mk-677 is linked to different kinds of benefit that go beyond the typical effects of SARMs. This is why a lot of people are understandably skeptical with the substance because you wouldn’t normally expect a mere SARM to achieve the sort of things that MK-677 does. However, the moment you learn that Ibutamoren is a growth hormone secretagogue and a selective agonist of the ghrelin receptor your mind will become more open to what the substance can really deliver.
MK-677 works by attaching itself to ghrelin receptors where it works similarly as the naturally occurring hormone Ghrelin. Trials show that Mk-677 signals the pituitary gland to secrete the growth hormone. The chemical process will also result in the release of a vital lean muscle building hormone known as IGF-1. This is precisely what makes the compound so popular in the bodybuilding industry.
It gets much better! Unlike exogenous hormones that may tamper with the levels of other hormones in the body, Ibutamoren does not interfere with other hormones in the body. You won’t experience an increase in the stress hormone cortisol and neither will you have to deal with the reduced production of the male sex hormone testosterone! Ibutamoren is essentially a useful performance-enhancing compound whose users won’t require PCT.
This working mechanism helps MK-677 to:
- Promote muscle growth
Mk-677 creates an anabolic surrounding perfect for muscle growth. This is achieved in two ways; one, like we’ve already highlighted above, Ibutamoren signals the pituitary gland to release the growth hormone which then stimulates the secretion of IGF-1 from the liver. Both the growth hormone and IGF-1 will work together to improve nitrogen retention and protein synthesis in the muscle tissues. This ensures that your muscles have the building blocks necessary not just for the growth of muscle tissue but also for the repair of any damaged tissues.
The ability of Ibutamoren to promote muscle growth is well backed by clinical trials. A double-blind study used Ibutamoren to treat obese subjects for two months. At the end of the study period, the scientists noted an increase in GH secretion which resulted in an increase in lean muscle mass among the obese subjects.
For the best muscle growth results, it is advisable that all Ibutamoren is taken alongside a proper diet and a robust workout regimen. This ensures better and faster results.
To further investigate Ibutamoren’s ability to prevent muscle wasting, the substance was subjected to another trial involving food-deprived participants. Not only did Ibutamoren prevent further muscle wasting but it also reversed both the condition and the protein loss that had taken place.
- Improve bone density
One of the many benefits of an increase in growth hormone is the enhanced ability of your body to create stronger bones. This was one of the several findings discovered in the double-blind, randomized controlled trial mentioned above.
Better bone density comes as great news to everyone. Take the elderly for instance, this population group usually finds it really difficult to move from one place to another without fracturing a bone, and that’s simply because of reduced bone density stemming from the decrease in GH levels. Studies show that Ibutamoren can be used by the elderly to deliver stronger and generally healthier bones.
Another trial was also undertaken to investigate the effects of Nutrobal involving 292 post-menopausal women. This trial reported that the oral growth hormone secretagogue MK-677 improved mineral density leading to stronger bones. It concluded that Ibutamoren can be used to prevent osteoporosis in post-menopausal women.
- Enhance longevity
Aging is as a result of many factors and a decrease in growth hormone is one of them. GH promotes the growth of new tissue cells and to supplement existing cells thereby improving the functions of tissues in the body. The hormone also helps in growing new cells to replace damaged ones. Therefore, when you are aging, and your body ceases to produce as much GH as is needed, different tissues will stop functioning correctly. This is why the elderly have more wrinkled skin, hair loss, etc.
Mk-677 boosts GH levels in the body, and this keeps the different tissues working optimally. This was confirmed in a study involving 65 adults aged between 60 to 81 years old.
- Improve the quality of sleep
There is a lot of evidence showing Nutrobal’s ability in promoting both the quality and quantity of REM sleep. Clinical trials and anecdotal evidence showed Ibutamoren to be useful for this purpose in both young and elderly people.
With sufficient quality sleep, your body will receive the rest it desperately needs for optimal recovery and for better productivity when working or in the gym.
- Enhance brain function
One of the most controversial benefits of Ibutamoren is its nootropic properties. Many people have always questioned how exactly a performance-enhancing substance can influence brain functions. Well, this happens in two key ways:
We’ve already established that Ibutamoren stimulates the release of IGF-1. High levels of IGF-1 are known to improve one’s learning ability and memory retention. This can be very useful for both young and elderly people.
We also know that Ibutamoren boosts the quality and quantity of REM sleep. This has been proved by multiple trials. When your body and especially brain is getting sufficient rest, it starts functioning at its peak. This will boost your focus and many other brain functions.
- Treat growth hormone deficiency
Trials have shown that MK-677 can be used to treat growth hormone deficiency in children. The compound increases the levels of IGF-1 and IGFBP-3 without interfering with glucose, prolactin, triiodothyronine, thyrotropin, thyroxine, cortisol or insulin.
In adults with severe growth hormone deficiency, Ibutamoren helped to increase both IGF-1 and IGFBP-3, but unfortunately, glucose and insulin levels also went up. This is perhaps the only instance where Nutrobal disrupted other hormone levels apart from GH.
- Healthier skin and hair
When the cells beneath your skin surface are damaged for whatever reasons like say the presence of free radicals, your skin tissues will stop functioning correctly. This leads to accumulation of toxins which should be eliminated, clogging of pores and many other issues. In the end, the user will witness acne breakout, black spots, wrinkled skin, etc.
The same thing applies when dealing with hair. Damaged cells result in unhealthy hair, and that’s when you start noticing your hair is falling off.
Growth hormone boosts the growth of cells enhancing your underlying skin tissue. After a few days or weeks of using Nutrobal, you should start seeing a clear and glowing skin. Your hair should also grow stronger.
- Heals Wounds
Some users have also seen their wounds heal faster due to using Ibutamoren. There is no scientific evidence to support this, but it may be due to the increase in GH which improves tissue growth and replaces damaged cells quickly.
Side Effects of Ibutamoren
Ibutamoren is a reasonably safe compound that can be used without causing any severe complications. Some of the minor adverse reactions that the user may experience include: an increase in appetite, muscle pain, and mild lower extremity edema.
In one study involving elderly hip fracture patients, the use of Nutrobal resulted in an increase in fasting blood glucose levels and reduced insulin sensitivity. It’s hence essential that all the elderly people using Ibutamoren should check their blood glucose levels regularly. They should also keep a close eye on carb intake.
A few of the patients in that study were also reported to be at risk for congestive heart failure. These patients had a history of heart failure though. It’s therefore possible that elderly individuals with a heart failure history run a high risk of experiencing the same condition if they use Ibutamoren.
Since Ibutamoren increases growth hormone and IGF-1 which in turn boosts the growth of cells, the substance can encourage the growth and spread of cancer cells. It’s for this reason that cancer patients are advised against using the compound. The dominant individuals should also avoid taking MK-677.
The fact that Ibutamoren does not interfere with testosterone production and it doesn’t disrupt other hormone levels should not dupe you into thinking that you don’t need to cycle it. Remember that MK-677 increases the levels of blood glucose in the system which can lead to insulin resistance in the long run.
There is also evidence showing that the incredible effects of Ibutamoren may start to slow down if you use the substance for too long. This is when a user notices a spike in growth hormone and IGF-1 in the first few months of using the compound, but then they start to slow down gradually. They could even begin to decline if you continue using the substance. Most studies show that GH and IGF-1 levels can start dropping after approximately 11 months of using Ibutamoren. Other trials have even shown the diminishing returns effects after just 6 months.
Another reason why cycling Nutrobal is essential is the fact that it works by stimulating the pituitary gland. As you may already know, this gland also has a negative feedback loop which is supposed to ensure that there is never too much secretion. Therefore, after releasing a lot of growth hormone for so long, the pituitary gland could naturally start to suppress the secretion of the GH.
From the above evidence, it is clear that you really need to cycle Ibutamoren. We’d advise you take Mk-677 for 6 months max followed by a break. This should help to maintain your blood sugar within healthy levels while also keeping the diminishing return effects at bay.
We’d also recommend that you monitor your blood sugar closely. In fact, you should check your fasting blood glucose levels before you even start using MK-677. Avoid using MK677 if the levels are high,. Various measures can be taken to bring the levels of fasting blood glucose down. These include: change in diet and overall lifestyle. You can also consider using insulin-sensitizing agents. In the event that none of these measures are successful in dropping your fasting blood glucose, we’d urge you to stay away from MK-677 completely.
MK-677 is widely available in an oral form which makes using it really convenient. Also, it has a half-life of 24 hours which means that you can take the substance just once per day. However, anecdotal data shows that high levels of Nurtobal taken instantly can lead to a spike in GH levels which could result in lethargy. To avoid this, we’d recommend that you split the dose to two taken at different times. This will maintain sufficient levels of Mk-677 in your system without negatively affecting your performance.
We usually urge beginners to start with the lowest doses possible. This should be anywhere between 10 to 15 mg per day for 12 weeks. You can then monitor your progress for several weeks before you start increasing the doses gradually. Experienced users can start with 20-25 mg per day for 12 weeks. Professional bodybuilders coming off cycle can take up to 50 mg per day, but this should strictly be limited to 8-week cycles.
Is It Legal?
Ibutamoren or Nutrobal is currently available as a research chemical only. This means that the GH secretagogue should not be sold for human consumption.
It’s important to always check on the regulations of every performance-enhancing drug you are eyeing before placing your order. This is because the laws vary from one state to another and from country to country. While the drug may be completely legal to buy for research purposes in the U.S, it may be a totally banned compound in another country. It’s all up to you to do your due diligence and ensure that you are not breaking any laws when placing your order for these substances.
In the United Kingdom, Mk-677 is permitted for personal use.
It’s important to remember that MK-677 is prohibited in professional sports. This substance can be detected in different doping tests, and hence it’s in your best interest to avoid using it if you are a professional athlete.
Bodybuilding Uses of Nutrobal
- Building lean muscle mass
Growth hormone and IGF-1 are essential for muscle growth. MK-677 helps in increasing both of these hormones resulting in a highly anabolic environment. In turn, this leads to an increase in lean muscle mass which is pretty much every bodybuilder’s dream.
MK-677 can also be stacked with selective androgen receptor modulators to gain even more lean muscle mass. An example of an MK-677 bulking stack includes 50 mg of Mk677, 10 mg of Testolone (RAD-140) and 10 mg of Ligandrol (LGD-4033). These doses should be taken every day. The high 50mg per day dose of MK-677 means that this stack is for the highly experienced bodybuilders only.
- Cutting or Recomposition
Ibutamoren can also be used when you want to reduce body fat percentage. It oxidizes fat burning it down leading to mild weight loss. Since MK-677 also promotes muscle growth, users will enjoy a decrease in body fat and an increase in lean muscle mass. This results in highly defined muscles and adorable vascularity.
For cutting or body recomposition, users can take 25 mg of MK-677, 20 mg of Cardarine (GW501516) and 50 mg of Andarine (S4) every day.
Recovery is very important for a serious bodybuilder who doesn’t want to waste any time due to swollen muscles or injuries. By increasing growth hormone, MK-677 promotes the growth of tendons, bones, and ligaments. The substance will also fight any preexisting conditions be it wounds or low bone density. You can incorporate Ibutamoren into your workout regimen to ensure that recovery is as smooth as possible.
Ibutamoren can also be used to boost overall well-being while also promoting muscle growth. For this purpose, one can stack 25 mg of MK-677 with 25 mg of Ostarine Ostabolic (MK-2866) per day.
Conclusion on Nutrobal
Being a selective agonist for ghrelin receptors, Ibutamoren is very unique and completely different from selective androgen receptor modulators. The compound yields the same bodybuilding effects achieved by other SARMs, but it is much safer. For instance, you will never have to worry about testosterone suppression and hence PCT won’t be necessary. Ibutamoren will also go a step further to deliver other results that you won’t find in regular SARMs. This includes healthier skin and hair and potential nootropic effects.
Conclusively, MK-677 is a brilliant substance with so much potential.